Description

5-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole is a high-value, protected boronic ester derivative of a methylated indole, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in developing kinase inhibitors, oncology drugs, and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science Research: Serves as a precursor for organic electronic materials, including organic light-emitting diodes (OLEDs) and conductive polymers.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: A vital reagent for methodology development and complex molecule synthesis in academic laboratories and CROs (Contract Research Organizations).
• Ligand & Catalyst Development: Used to construct sophisticated ligand frameworks for asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	5-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole
CAS No.	1426154-41-7
Molecular Formula	C15H20BNO2
Molecular Weight	257.14 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-methyl-1H-indole; 5-Methyl-1H-indole-4-boronic acid pinacol ester; 5-Methylindole-4-boronic acid pinacol ester; 4-Borono-5-methyl-1H-indole pinacol ester; Pinacol 5-methyl-1H-indole-4-boronate; 5-Methyl-4-(pinacolatoboryl)-1H-indole; 1H-Indole-4-boronic acid, 5-methyl-, 1,1,1,1-tetramethyl-1,3,2-dioxaborolan-2-yl ester
EINECS	Contact for details

Quality Control

Our 5-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, NMR, and LC-MS. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and reliability for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (argon or nitrogen) for long-term preservation. Recommended storage temperature: 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.