Description

Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indene-1-carboxylate is a high-purity, synthetically valuable boronic ester derivative, serving as a critical building block in modern organic synthesis. Its primary value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and fine chemical production.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing the dihydroindene scaffold.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronate ester coupling partner for the introduction of the functionalized indane moiety into complex molecules.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides requiring specific, sterically defined structures.
• Material Science: Building block for creating organic electronic materials, such as those used in OLEDs and semiconductors, where precise molecular geometry is crucial.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and labeled compounds for biochemical and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CMOs for bespoke synthesis projects requiring this specific boronic ester functionality.

Basic Information

Product Name	Methyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1H-Indene-1-Carboxylate
CAS No.	1423700-47-3
Molecular Formula	C17H23BO4
Molecular Weight	302.18 g/mol
Synonyms	Methyl 1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indene-5-carboxylate; 1H-Indene-1-carboxylic acid, 2,3-dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; 5-Pinacolatoboryl-2,3-dihydro-1H-indene-1-carboxylic acid methyl ester; Methyl 5-(pinacolatoboryl)-2,3-dihydro-1H-indene-1-carboxylate; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indane-1-carboxylic acid methyl ester; CAS 1423700-47-3
EINECS	Contact for details

Quality Control

Our Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indene-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis by GC, to ensure it meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.