Description

Hc≡C-Ch2-Peg8-Sh CAS NO 1422540-92-8 is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal alkyne and a thiol group, separated by a flexible PEG8 spacer. This compound is a critical reagent for site-specific bioconjugation and click chemistry applications, enabling the controlled attachment of biomolecules, polymers, or nanoparticles. It is primarily utilized by researchers and process developers in the pharmaceutical, biotechnology, and advanced materials sectors for creating stable, well-defined conjugates.

Application

• Bioconjugation and Protein Labeling: Site-specific modification of proteins, antibodies, or peptides via thiol-maleimide or thiol-haloacetyl chemistry, with the alkyne handle for subsequent click chemistry functionalization.
• PEGylation Reagent: Used to introduce a hydrophilic PEG spacer to drug molecules or surfaces to improve solubility, reduce immunogenicity, and enhance circulation time.
• Surface Functionalization: Immobilization of biomolecules onto gold, quantum dot, or other nanoparticle surfaces through the thiol group for biosensor and diagnostic assay development.
• Polymer Synthesis and Modification: Acts as a versatile building block for synthesizing block copolymers or functionalizing polymer backbones via thiol-ene or copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions.
• Crosslinking Agent: Creation of hydrogel networks or crosslinked protein assemblies by reacting with complementary functional groups.
• Drug Delivery System Fabrication: Construction of targeted drug delivery carriers by linking therapeutic payloads to targeting ligands.

Basic Information

Product Name	Hc≡C-Ch2-Peg8-Sh
CAS No.	1422540-92-8
Molecular Formula	C₂₃H₄₄O₉S
Molecular Weight	508.66 g/mol
Synonyms	Propargyl-PEG8-thiol; 1-Propargyl-3,6,9,12,15,18,21,24-octaoxaheptacosane-27-thiol; Alkyne-PEG8-SH; Thiol-PEG8-alkyne; 27-Mercapto-3,6,9,12,15,18,21,24-octaoxaheptacos-1-yne; Heterobifunctional PEG Alkyne Thiol; Propargyl-PEG8-SH; 8-Arm PEG Alkyne Thiol (common trade name style)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and process development. Each batch is characterized to confirm identity, purity, and functional group integrity. Certificates of Analysis (COA) are available upon request, detailing key parameters such as assay by NMR, thiol titration, and absence of critical impurities.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the product under an inert atmosphere (argon or nitrogen) at -20°C or below. This compound is hygroscopic (moisture-sensitive) and easily oxidized; allow the vial to equilibrate to room temperature in a desiccator before opening to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (NMR)	≥ 90%
Thiol Content (Titration)	≥ 85% of theoretical
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.