Description

Hc≡C-Ch2-Peg6-Sh CAS NO 1422540-91-7 is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal alkyne and a thiol group, separated by a hexaethylene glycol spacer. This compound is critical for creating stable, site-specific bioconjugates and functionalized materials via orthogonal click chemistry and thiol-based coupling reactions. It is primarily needed by researchers and manufacturers in bioconjugation, pharmaceutical development, nanotechnology, and surface functionalization who require precise and reliable crosslinking agents.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Site-specific coupling of payloads (drugs, dyes, toxins) to proteins, antibodies, or peptides.
• PEGylation and Drug Delivery Systems: Functionalizing nanoparticles, liposomes, or therapeutic molecules to improve solubility, stability, and pharmacokinetics.
• Surface Chemistry and Biosensor Fabrication: Immobilizing biomolecules or creating functional monolayers on gold or other thiol-reactive surfaces for sensor applications.
• Polymer Chemistry and Material Science: Serving as a versatile building block for synthesizing functional polymers, hydrogels, and smart materials.
• Diagnostic Reagent Preparation: Conjugating detection probes (e.g., fluorescent tags) to targeting ligands for immunoassays and imaging.
• Click Chemistry Tool: The terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) for modular assembly of complex architectures.

Basic Information

Product Name	Hc≡C-Ch2-Peg6-Sh
CAS No.	1422540-91-7
Molecular Formula	C₂₀H₃₈O₇S
Molecular Weight	422.58 g/mol
Synonyms	Propargyl-PEG6-thiol; Alkyne-PEG6-SH; 1-Propargyl-3,6,9,12,15,18-hexaoxahenicosane-21-thiol; 21-Mercapto-3,6,9,12,15,18-hexaoxahenicos-20-yn-1-ol; Heterobifunctional PEG Alkyne Thiol; HS-PEG6-Propargyl; Thiol-PEG6-Alkyne; Propargyl-PEG6-SH
EINECS	Contact for details

Quality Control

Our Hc≡C-Ch2-Peg6-Sh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and titration for functional group quantification, to ensure it meets the high standards required for research and commercial applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and easily oxidized nature. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Thiol Titration)	≥ 90%
Functional Group Assay (Alkyne Quantification)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.