Description

3-(4-Methylpiperazin-1-Yl)Indolizine-6-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a unique heterocyclic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in the fields of oncology and central nervous system (CNS) disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers seeking reliable, high-quality building blocks for complex synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel small-molecule drug candidates.
• Oncology Research: Used in the development of targeted cancer therapies due to its indolizine-piperazine scaffold, which is common in kinase inhibitors.
• CNS Drug Discovery: Employed in creating compounds for neurological and psychiatric disorder research.
• Chemical Biology: Acts as a probe or ligand in the study of biological pathways and protein interactions.
• Process Chemistry: Utilized for scale-up and optimization of synthetic routes in pilot and commercial manufacturing.
• Academic Research: Provides a versatile scaffold for synthetic and medicinal chemistry studies in university and institutional labs.

Basic Information

Product Name	3-(4-Methylpiperazin-1-Yl)Indolizine-6-Carboxylic Acid
CAS No.	1422134-07-3
Molecular Formula	C15H17N3O2
Molecular Weight	271.32 g/mol
Synonyms	3-(4-Methyl-1-piperazinyl)indolizine-6-carboxylic acid; 6-Carboxy-3-(4-methylpiperazin-1-yl)indolizine; 1-Methyl-4-(6-carboxyindolizin-3-yl)piperazine; Indolizine-6-carboxylic acid, 3-(4-methyl-1-piperazinyl)-; 1422134-07-3; 3-(4-Methylpiperazin-1-yl)-1H-pyrrolo[1,2-a]azepine-8-carboxylic acid (tautomeric form)
EINECS	Contact for details

Quality Control

Our production of 3-(4-Methylpiperazin-1-Yl)Indolizine-6-Carboxylic Acid adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.