Description

Mal-Peg3-Alcohol CAS NO 1421933-37-0 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group at one terminus and a hydroxyl group at the other, connected by a triethylene glycol spacer. This compound is a critical building block in bioconjugation chemistry, enabling the site-specific attachment of biomolecules, drugs, or probes to thiol-containing targets. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries for developing antibody-drug conjugates (ADCs), protein and peptide modifications, and advanced drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key intermediate for constructing cleavable or non-cleavable linkers, connecting cytotoxic payloads to monoclonal antibodies via thiol-maleimide chemistry.
• Protein and Peptide PEGylation: Used for site-specific modification of cysteine residues in proteins and peptides to improve pharmacokinetics, solubility, and stability.
• Surface Functionalization: Facilitates the immobilization of thiolated biomolecules onto hydroxyl-presenting surfaces or particles for biosensor and microarray development.
• Cross-linking Agent: Acts as a heterobifunctional cross-linker to conjugate hydroxyl-containing molecules (via further derivatization) with thiol-containing molecules.
• Polymer Therapeutics: A foundational reagent for synthesizing sophisticated polymer-drug conjugates and stimuli-responsive nanocarriers.
• Diagnostic Probe Conjugation: Enables the labeling of antibodies, proteins, or oligonucleotides with fluorescent dyes, enzymes, or other detection moieties for diagnostic assays.

Basic Information

Product Name	Mal-Peg3-Alcohol
CAS No.	1421933-37-0
Molecular Formula	C15H25NO7
Molecular Weight	331.36 g/mol
Synonyms	3-Maleimidopropanol-PEG3; Maleimide-PEG3-alcohol; 3-(2-(2-(3-Maleimidopropoxy)ethoxy)ethoxy)propan-1-ol; 1-(3-(2-(2-(3-Hydroxypropoxy)ethoxy)ethoxy)propyl)-1H-pyrrole-2,5-dione; Mal-PEG3-OH; Maleimide-PEG3-OH; mPEG3-maleimide; PEG3 maleimide alcohol
EINECS	Contact for details

Quality Control

Our Mal-Peg3-Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for research and bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.