Description

4,4-Difluoro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is a high-purity fluorinated heterocyclic building block essential for modern pharmaceutical and agrochemical research. Its core value lies in the strategic incorporation of fluorine atoms, which can dramatically alter a molecule's metabolic stability, lipophilicity, and binding affinity. This compound is primarily needed by medicinal chemists and process development scientists in the pharmaceutical industry for the synthesis of novel drug candidates targeting central nervous system disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key fluorinated synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) drugs.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to improve the pharmacokinetic and pharmacodynamic properties of drug-like molecules.
• Agrochemical Research: Serves as a building block for developing advanced crop protection agents and pesticides, where fluorine substitution enhances bioactivity.
• Chemical Biology: Employed as a probe or labeled compound in biochemical assays and mechanism-of-action studies.
• Process Chemistry: Used in scaling up synthetic routes for the commercial production of fluorinated fine chemicals.
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies involving fluorinated isoquinoline scaffolds.

Basic Information

Item	Details
Product Name	4,4-Difluoro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
CAS No.	1421604-19-4
Molecular Formula	C9H10ClF2N
Molecular Weight	205.63 g/mol
Synonyms	4,4-Difluoro-1,2,3,4-tetrahydroisoquinoline HCl; 4,4-Difluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride; 1,2,3,4-Tetrahydro-4,4-difluoro-isoquinoline hydrochloride; 4,4-Difluoro-1,2,3,4-tetrahydroisoquinolinium chloride; 4,4-Difluoro THIQ HCl; DF-THIQ HCl
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for your research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.