Description

n-(1-Acetyl-3,3-Dimethyl-2,3-Dihydro-1H-Indol-6-Yl)-2-Chloronicotinamide is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the discovery and development of new drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders or oncological pathways.
• Organic Synthesis Building Block: Used in research-scale and pilot-scale organic chemistry for constructing complex indole and nicotinamide-based heterocycles.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop new chemical entities with optimized biological activity and pharmacokinetic properties.
• Contract Manufacturing: Supplied to CDMOs for the cGMP-compliant production of clinical trial materials and commercial APIs.
• Biochemical Research: May be utilized as a tool compound or ligand in biochemical assays to study protein interactions and enzyme inhibition.

Basic Information

Product Name	n-(1-Acetyl-3,3-Dimethyl-2,3-Dihydro-1H-Indol-6-Yl)-2-Chloronicotinamide
CAS No.	1420999-91-2
Molecular Formula	C18H18ClN3O2
Molecular Weight	343.81 g/mol
Synonyms	2-Chloro-N-[1-acetyl-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl]pyridine-3-carboxamide; 2-Chloronicotinamide, N-(1-acetyl-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-; 6-[[(2-Chloro-3-pyridinyl)carbonyl]amino]-1-acetyl-3,3-dimethyl-2,3-dihydro-1H-indole; 1H-Indole-6-carboxamide, 2,3-dihydro-1-acetyl-3,3-dimethyl-N-(2-chloro-3-pyridinyl)-; (1-Acetyl-3,3-dimethyl-2,3-dihydroindol-6-yl)-(2-chloropyridin-3-yl)carboxamide
EINECS	Contact for details

Quality Control

Our n-(1-Acetyl-3,3-Dimethyl-2,3-Dihydro-1H-Indol-6-Yl)-2-Chloronicotinamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.