Description

5-[[(Dimethylamino)Iminomethyl]Amino]-2-Oxopentanoic Acid-D6 is a stable isotope-labeled analog of a key glutamine derivative, where six hydrogen atoms are replaced with deuterium. This high-purity labeled compound is essential for creating reliable internal standards in quantitative mass spectrometry, ensuring accurate and reproducible analytical results. It is primarily used by pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism and pharmacokinetics (DMPK) studies, proteomics, and biomarker discovery.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the precise quantification of its unlabeled counterpart in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) by providing a stable isotope-labeled spike for mass spectrometric detection.
• Biomarker Research: Used in targeted metabolomics and proteomics workflows to quantify specific metabolic pathway intermediates or peptides with high fidelity.
• Pharmaceutical R&D: Supports method development and validation in bioanalytical laboratories for preclinical and clinical studies, ensuring data meets regulatory standards.
• Isotope Dilution Mass Spectrometry (IDMS): A fundamental component in this gold-standard quantitative technique, minimizing matrix effects and instrument variability.

Basic Information

Product Name	5-[[(Dimethylamino)Iminomethyl]Amino]-2-Oxopentanoic Acid-D6
CAS No.	1419723-92-4
Molecular Formula	C8D6H9N3O3
Molecular Weight	207.21 g/mol (deuterated form)
Synonyms	2-Oxo-5-[(E)-(dimethylamino)methanimidamido]pentanoic-3,3,4,4,5,5-d6 Acid; L-Glutamine, N2-[(dimethylamino)methylene]-5-oxo-,-d6; Deuterated N2-[(Dimethylamino)methylene]glutamine; N'-[(Dimethylamino)methylidene]-5-oxo-DL-glutamine-d6; Isotopically Labeled Glutamine Derivative; Stable Isotope-Labeled Internal Standard (for Glutamine Analogs); MS Standard-d6
EINECS	Contact for details

Quality Control

Every batch of 5-[[(Dimethylamino)Iminomethyl]Amino]-2-Oxopentanoic Acid-D6 is manufactured and analyzed under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results for identity, purity (HPLC), isotopic enrichment (NMR/MS), and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.