Description

1-(5-Chloro-3-Indolyl)-2,2,2-Trifluoroethanone is a high-purity, specialized trifluoromethyl ketone derivative of a chlorinated indole. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block for the synthesis of complex bioactive molecules. It is primarily required by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibition.
• Agrochemical Research: Building block for synthesizing new-generation pesticides and herbicides with enhanced efficacy.
• Chemical Biology Probe: Used in research to study biological pathways and protein-ligand interactions due to its unique trifluoromethyl ketone moiety.
• Material Science Precursor: Intermediate in the synthesis of specialty polymers and organic electronic materials.
• Fluorine Chemistry: Serves as a valuable substrate for introducing the trifluoromethyl group into more complex molecular architectures.

Basic Information

Product Name	1-(5-Chloro-3-Indolyl)-2,2,2-Trifluoroethanone
CAS No.	1419517-55-7
Molecular Formula	C11H5ClF3NO
Molecular Weight	259.61 g/mol
Synonyms	5-Chloro-3-(2,2,2-trifluoroacetyl)indole; 5-Chloro-3-trifluoroacetylindole; 1-(5-Chloro-1H-indol-3-yl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(5-chloro-1H-indol-3-yl)ethanone; 5-Chloro-3-indolyl trifluoromethyl ketone; 1-(5-Chloroindol-3-yl)-2,2,2-trifluoroethanone
EINECS	Contact for details

Quality Control

Our 1-(5-Chloro-3-Indolyl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment to guarantee batch-to-batch consistency and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.