Description

2-Bromo-4-(1,1-Difluoroethyl)Pyridine is a high-value, multi-functional pyridine derivative and a key building block in advanced organic synthesis. This compound matters for its unique halogenated and fluorinated structure, which is critical for modulating the physicochemical and biological properties of target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the difluoroethyl group can enhance metabolic stability and lipophilicity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille) to create complex biaryl structures.
• Ligand and Catalyst Development: Utilized in the preparation of novel nitrogen-containing ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: Acts as a valuable reagent for studying the effects of fluorine substitution in medicinal and materials chemistry.

Basic Information

Product Name	2-Bromo-4-(1,1-Difluoroethyl)Pyridine
CAS No.	1419221-58-1
Molecular Formula	C7H6BrF2N
Molecular Weight	222.03 g/mol
Synonyms	4-(1,1-Difluoroethyl)-2-bromopyridine; 2-Bromo-4-(1,1-difluoroethyl)pyridine; 2-Bromo-4-(α,α-difluoroethyl)pyridine; Pyridine, 2-bromo-4-(1,1-difluoroethyl)-; 1419221-58-1; 2-Bromo-4-(difluoroethyl)pyridine; 2-Br-4-(1,1-F2Et)Py
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-(1,1-Difluoroethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.