Description

Methyl 6,6-Difluorospiro[3.3]heptane-2-carboxylate is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and difluorinated molecular architecture. This compound is specifically engineered to serve as a critical building block in modern medicinal chemistry, offering significant advantages for modulating the physicochemical and metabolic properties of drug candidates. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new small-molecule therapeutics, particularly in CNS, oncology, and metabolic disease research.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluorinated spirocyclic moiety can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty monomers or ligands in the development of novel polymers and functional materials.
• Medicinal Chemistry Probe: Employed in structure-activity relationship (SAR) studies to investigate the impact of rigid, fluorinated scaffolds on drug-like properties such as lipophilicity and conformational restraint.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and process development programs for global clients.

Basic Information

Product Name	Methyl 6,6-Difluorospiro[3.3]heptane-2-carboxylate
CAS No.	1419101-40-8
Molecular Formula	C10H12F2O2
Molecular Weight	202.20 g/mol
Synonyms	Methyl 6,6-difluorospiro[3.3]heptane-2-carboxylate; 6,6-Difluorospiro[3.3]heptane-2-carboxylic acid methyl ester; Spiro[3.3]heptane-2-carboxylic acid, 6,6-difluoro-, methyl ester; 2-Carbomethoxy-6,6-difluorospiro[3.3]heptane
EINECS	Contact for details

Quality Control

Our production of Methyl 6,6-Difluorospiro[3.3]heptane-2-carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and tested against rigorous in-house specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by GC/HPLC), and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider using an inert atmosphere to preserve optimal quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.