Description

2-(5-Fluoro-2-Methyl-3-Nitrophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated and nitrated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific fluorinated aromatic motifs.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, such as OLEDs and semiconductors, via cross-coupling polymerization.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to create tagged molecules and probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Item	Details
Product Name	2-(5-Fluoro-2-Methyl-3-Nitrophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1418128-32-1
Molecular Formula	C13H17BFNO4
Molecular Weight	281.09 g/mol
Synonyms	(5-Fluoro-2-methyl-3-nitrophenyl)boronic acid pinacol ester; 2-Methyl-5-fluoro-3-nitrophenylboronic acid pinacol ester; Pinacol (5-fluoro-2-methyl-3-nitrophenyl)boronate; 5-Fluoro-2-methyl-3-nitrobenzeneboronic acid pinacol ester; (5-Fluoro-2-methyl-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 1418128-32-1
EINECS	Contact for details

Quality Control

Our 2-(5-Fluoro-2-Methyl-3-Nitrophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity suitable for demanding synthetic applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.