Description

(4-Aminomethyl-Piperidin-1-Yl)-Isoquinolin-1-Yl-Methanone Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1417793-37-3. This compound is critical for research and development in medicinal chemistry, offering a key building block for the synthesis of novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new drug candidates, particularly in areas such as oncology and central nervous system (CNS) disorders.

Application

This specialized intermediate serves as a crucial component in sophisticated chemical synthesis pathways. Its primary applications include:

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new molecular entities.
• API Development: Serves as a precursor in the development and scale-up of active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized as a tool compound in biochemical assays and target validation studies.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule synthesis.
• Library Synthesis: Valuable for creating focused chemical libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	(4-Aminomethyl-Piperidin-1-Yl)-Isoquinolin-1-Yl-Methanone Hydrochloride
CAS No.	1417793-37-3
Molecular Formula	C₁₆H₂₀N₃O₂·HCl
Molecular Weight	323.81 g/mol (Free base: 286.35 g/mol)
Synonyms	1-(Isoquinoline-1-carbonyl)piperidine-4-methanamine hydrochloride; 4-(Aminomethyl)-1-(isoquinoline-1-carbonyl)piperidinium chloride; (4-Aminomethyl-1-piperidyl)-isoquinolin-1-yl-methanone hydrochloride; 1-Piperidinecarboxamide, 4-(aminomethyl)-N-1-isoquinolinyl-, monohydrochloride; Isoquinoline-1-carboxylic acid (4-aminomethyl-piperidin-1-yl)-amide hydrochloride; (4-Aminomethylpiperidin-1-yl)(isoquinolin-1-yl)methanone hydrochloride; 1417793-37-3; UNII-Contact for details
EINECS	Contact for details

Quality Control

Our (4-Aminomethyl-Piperidin-1-Yl)-Isoquinolin-1-Yl-Methanone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.