Description

(1S,3R,5S)-2-(tert-Butoxycarbonyl)-2-Azabicyclo[3.1.0]Hexane-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a constrained bicyclic scaffold. This compound is a critical chiral building block for the synthesis of complex drug molecules, offering precise stereochemical control. It is primarily utilized by research and development teams in the pharmaceutical and biotechnology sectors for the development of novel therapeutics, including protease inhibitors and other biologically active compounds. Its defined stereochemistry is essential for ensuring the efficacy and safety profile of the final active pharmaceutical ingredient (API).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs), particularly those targeting viral proteases and neurological pathways.
• Protease Inhibitor Development: Serves as a core structural component in the research and production of novel protease inhibitor drugs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities with therapeutic potential.
• Asymmetric Synthesis: Employed as a building block in stereoselective chemical reactions to construct molecules with high enantiomeric purity.
• Contract Manufacturing (CDMO): Supplied to Contract Development and Manufacturing Organizations for cGMP-compliant production of clinical trial materials and commercial APIs.
• Bioconjugation & Peptidomimetics: Its carboxylic acid functionality allows for coupling reactions to create peptide-like (peptidomimetic) compounds with enhanced metabolic stability.

Basic Information

Product Name	(1S,3R,5S)-2-(tert-Butoxycarbonyl)-2-Azabicyclo[3.1.0]Hexane-3-Carboxylic Acid
CAS No.	1417743-41-9
Molecular Formula	C12H19NO4
Molecular Weight	241.28 g/mol
Synonyms	(1S,3R,5S)-2-((tert-Butoxy)carbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid; (1S,3R,5S)-2-(Boc)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid; (1S,3R,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid, 2-[(1,1-dimethylethoxy)carbonyl]-; (1S,3R,5S)-Boc-2-azabicyclo[3.1.0]hexane-3-carboxylic acid; (1S,3R,5S)-2-(tert-Butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid; 2-Azabicyclo[3.1.0]hexane-3-carboxylic acid, 2-[(1,1-dimethylethoxy)carbonyl]-, (1S,3R,5S)-; Bicyclo[3.1.0]hexane-3-carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our (1S,3R,5S)-2-(tert-Butoxycarbonyl)-2-Azabicyclo[3.1.0]Hexane-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical R&D and cGMP manufacturing. Specifications typically include chiral purity, chemical purity (HPLC), and identification. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.