Description

1-(2,2,2-Trifluoroethyl)-1H-Pyrazol-4-Yl-4-Boronic Acid is a high-value organoboron building block, specifically a pyrazole-substituted boronic acid derivative, essential for modern cross-coupling reactions. Its core value lies in enabling the precise synthesis of complex molecules, particularly in the development of pharmaceuticals and advanced materials. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key reagent in Suzuki-Miyaura cross-coupling reactions for synthesizing active pharmaceutical ingredients (APIs), especially those containing trifluoroethyl and pyrazole motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific heterocyclic structures for enhanced activity.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and semiconductors, where the pyrazole unit can modify electronic properties.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and inhibitors for studying biological pathways and enzyme functions.
• Ligand Synthesis for Catalysis: Acts as a precursor for creating specialized ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A critical component for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-(2,2,2-Trifluoroethyl)-1H-Pyrazol-4-Yl-4-Boronic Acid
CAS No.	1416786-60-1
Molecular Formula	C7H8BF3N2O2
Molecular Weight	207.96 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole; 1-(2,2,2-Trifluoroethyl)-1H-pyrazole-4-boronic acid; 1-(2,2,2-Trifluoroethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1H-Pyrazole-4-boronic acid, 1-(2,2,2-trifluoroethyl)-; [1-(2,2,2-Trifluoroethyl)pyrazol-4-yl]boronic acid; 1-(Trifluoroethyl)pyrazole-4-boronic acid; B-[1-(2,2,2-Trifluoroethyl)-1H-pyrazol-4-yl]boronic acid
EINECS	Contact for details

Quality Control

Our 1-(2,2,2-Trifluoroethyl)-1H-Pyrazol-4-Yl-4-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 1.0%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.