Description

4-Bromo-7-Fluoroisoquinoline is a high-purity, versatile heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its dual functionalization, providing distinct reactive sites for the construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially kinase inhibitors and other biologically active molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides due to its unique fluorinated isoquinoline scaffold.
• Material Science: Serves as a building block for creating organic semiconductors, liquid crystals, and fluorescent dyes.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig aminations.
• Functional Group Transformation: The fluorine atom and the isoquinoline nitrogen allow for further selective derivatization to create diverse chemical libraries.
• Ligand Synthesis: Can be utilized to prepare novel chelating ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Bromo-7-Fluoroisoquinoline
CAS No.	1416500-77-0
Molecular Formula	C9H5BrFN
Molecular Weight	226.05 g/mol
Synonyms	7-Fluoro-4-bromoisoquinoline; 4-Bromo-7-fluoroisoquinoline; Isoquinoline, 4-bromo-7-fluoro-; 1416500-77-0; 4-Br-7-F-Isoquinoline
EINECS	Contact for details

Quality Control

Our 4-Bromo-7-Fluoroisoquinoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.