Description

(2-Amino-2,3-Dihydro-1H-Inden-2-Yl)Phosphonic Acid Hydrochloride is a high-purity, organophosphorus building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals and bioactive molecules, particularly those targeting bone-related disorders and enzyme inhibition. Pharmaceutical researchers and fine chemical manufacturers need this material for constructing complex molecular architectures where the unique indane-phosphonic acid scaffold is required. Its availability in a stable hydrochloride salt form facilitates handling and integration into sensitive synthetic routes.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel drug candidates, particularly bisphosphonate analogs and enzyme inhibitors.
• Protease Inhibitor Research: Used in the development of inhibitors for metalloproteases and other enzyme targets due to its phosphonic acid moiety.
• Bone-Targeting Molecule Development: Serves as a precursor for compounds designed to treat osteoporosis and other bone metabolism diseases.
• Ligand Synthesis for Catalysis: Employed in creating chiral phosphonate ligands for asymmetric synthesis and metal-organic frameworks (MOFs).
• Agrochemical Research: Intermediate in the development of new herbicides and plant growth regulators with specific mode-of-action.
• Chemical Biology Probe Development: Utilized to create activity-based probes for studying phosphonate-related biochemical pathways.

Basic Information

Product Name	(2-Amino-2,3-Dihydro-1H-Inden-2-Yl)Phosphonic Acid Hydrochloride
CAS No.	1416354-35-2
Molecular Formula	C9H13ClNO3P
Molecular Weight	249.63 g/mol
Synonyms	2-Amino-2,3-dihydro-1H-indene-2-phosphonic acid hydrochloride; 2-Aminoindane-2-phosphonic acid HCl; 2-Amino-1-indanephosphonic acid hydrochloride; (2-Amino-2,3-dihydro-1H-inden-2-yl)phosphonic acid HCl; AIA hydrochloride; 1H-Indene-2-phosphonic acid, 2-amino-2,3-dihydro-, hydrochloride (1:1); 1416354-35-2; 2-Aminoindan-2-ylphosphonic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (2-Amino-2,3-Dihydro-1H-Inden-2-Yl)Phosphonic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D and fine chemical synthesis. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available for every lot. We support compliance with relevant guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.