Description

3-Cyclobutyl-1H-Indazole is a high-purity, advanced pharmaceutical intermediate belonging to the indazole class of heterocyclic compounds. This compound serves as a critical building block in modern medicinal chemistry, enabling the synthesis of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, particularly for applications in oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: Serves as a privileged structure in the design and synthesis of potential kinase inhibitors for targeted cancer therapies.
• Biochemical Tool Compound: Employed in biochemical assays and as a reference standard for pharmacological studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.

Basic Information

Item	Details
Product Name	3-Cyclobutyl-1H-Indazole
CAS No.	1415715-80-8
Molecular Formula	C11H12N2
Molecular Weight	172.23 g/mol
Synonyms	3-Cyclobutyl-1H-indazole; 3-Cyclobutylindazole; 1H-Indazole, 3-cyclobutyl-; 3-Cyclobutyl-1H-pyrazolo[3,4-b]pyridine (related structure); Cyclobutylindazole; CB-Indazole; Indazole-3-cyclobutane
EINECS	Contact for details

Quality Control

Our 3-Cyclobutyl-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled and stored away from direct light exposure to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.