Description

[2H6]-Azetidine CAS NO 1415638-24-2 is a deuterium-labeled analog of the four-membered saturated heterocycle, azetidine, where six hydrogen atoms are replaced by the stable isotope deuterium. This isotopically labeled compound is a critical tool in pharmaceutical research and development, enabling precise metabolic and pharmacokinetic studies through advanced analytical techniques like mass spectrometry. It is primarily utilized by researchers and scientists in the fields of medicinal chemistry, drug discovery, and analytical method development for creating internal standards and tracing molecular pathways.

Application

• Internal Standard for Mass Spectrometry: Serves as a crucial reference compound in quantitative LC-MS and GC-MS analysis for accurate measurement of unlabeled azetidine or related metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to trace the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical candidates containing the azetidine moiety.
• Mechanistic Biochemical Research: Facilitates the investigation of reaction mechanisms and enzymatic processes involving azetidine rings without interference from kinetic isotope effects associated with heavier isotopes.
• Synthetic Intermediate for Labeled Compounds: Acts as a building block for the synthesis of more complex deuterium-labeled molecules for use in various research applications.
• Analytical Method Development and Validation: Essential for developing highly sensitive and specific analytical assays in compliance with regulatory guidelines for bioanalysis.

Basic Information

Product Name	[2H6]-Azetidine
CAS No.	1415638-24-2
Molecular Formula	C3[2H6]NH
Molecular Weight	~61.12 g/mol
Synonyms	Perdeuteroazetidine; Azetidine-d6; Hexadeuteroazetidine; Fully Deuterated Azetidine; [2H6]-Trimethyleneimine; 1,2,2,3,3,3-Hexadeuteroazetidine; Deuterated Azacyclobutane
EINECS	Contact for details

Quality Control

Every batch of [2H6]-Azetidine is produced and analyzed under strict quality management protocols to ensure the highest isotopic and chemical purity for research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic enrichment (D%), chemical purity, and solvent residues are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere after opening and stored away from moisture and heat sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Isotopic Enrichment (D%)	≥ 98 atom % D
Chemical Purity (GC or HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.