Description

Methyl 5-((4-Bromo-2-Fluorophenyl)Amino)-4-Fluoro-1-Methyl-1H-Benzo[D]Imidazole-6-Carboxylate CAS NO 1415559-93-1 is a highly specialized, fluorinated benzimidazole derivative engineered for precision applications in pharmaceutical research and advanced organic synthesis. Its unique substitution pattern—featuring dual fluorine atoms, a bromoanilino moiety, and a methyl ester group—confers exceptional target selectivity and metabolic stability, making it a critical intermediate in the development of kinase inhibitors and antitumor agents. This compound is primarily utilized by R&D teams in global pharmaceutical CROs, API manufacturers, and medicinal chemistry laboratories engaged in structure–activity relationship (SAR) studies and lead optimization programs.

Application

• Key synthetic intermediate in the preparation of BTK (Bruton’s tyrosine kinase) and FLT3 inhibitors for oncology drug candidates
• Building block for structure–activity relationship (SAR) profiling of next-generation benzimidazole-based antiproliferative agents
• Substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald–Hartwig) to introduce aryl/heteroaryl pharmacophores
• Core scaffold in the design of fluorescent probes and PET tracer precursors due to its tunable electronic properties and halogen handles
• Reference standard for HPLC and LC-MS/MS method development in pharmaceutical quality control laboratories
• Material for crystallinity and polymorph screening studies in preformulation development

Basic Information

Product Name	Methyl 5-((4-Bromo-2-Fluorophenyl)Amino)-4-Fluoro-1-Methyl-1H-Benzo[D]Imidazole-6-Carboxylate
CAS No.	1415559-93-1
Molecular Formula	C16H12BrF2N3O2
Molecular Weight	412.19 g/mol
Synonyms	MBFIMC; Methyl 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate; 1415559-93-1; Benzimidazole derivative 16; BZI-4F-Br; Fluoro-bromo-methylbenzimidazole carboxylate; 5-((4-Bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is verified for identity, assay, residual solvents, heavy metals, and related substances using validated HPLC, NMR, and LC-MS methods. Certificates of Analysis (COA) are available upon request and include full chromatograms, spectral data, and conformance statements against internal specifications aligned with ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Avoid exposure to moisture and elevated temperatures. Due to its light-sensitive nature, handling should occur under amber lighting or in low-light conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time matches reference standard
Identification (IR)	Characteristic peaks consistent with structure
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	≤ 1.0% total impurities; individual unknown ≤ 0.1%
Residual Solvents (GC)	MeOH ≤ 3000 ppm; DCM ≤ 600 ppm
Water (Karl Fischer)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.