Description

5-Bromo-6-Fluoro-1-Methylindazol-3-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated indazole core structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers in the production of targeted therapeutics, including kinase inhibitors and other small molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel, targeted small molecule therapeutics, particularly in oncology and anti-inflammatory research.
• Kinase Inhibitor Development: Used as a core scaffold or precursor in the design and synthesis of potent and selective kinase inhibitors due to its indazole pharmacophore.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization campaigns in drug discovery programs.
• Biochemical Probe Synthesis: Employed in creating chemical tools and probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and APIs.
• Academic Research: Used in university and institutional labs for fundamental research in heterocyclic chemistry and drug design.

Basic Information

Product Name	5-Bromo-6-Fluoro-1-Methylindazol-3-Amine
CAS No.	1414029-30-3
Molecular Formula	C8H7BrFN3
Molecular Weight	244.07 g/mol
Synonyms	1-Methyl-5-bromo-6-fluoro-1H-indazol-3-amine; 5-Bromo-6-fluoro-1-methyl-1H-indazol-3-amine; 3-Amino-5-bromo-6-fluoro-1-methylindazole; 1H-Indazol-3-amine, 5-bromo-6-fluoro-1-methyl-; 1414029-30-3; 5-Br-6-F-1-Me-indazol-3-NH2
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-6-Fluoro-1-Methylindazol-3-Amine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.