Description

Hc≡C-Ch2-Peg3-Sh CAS NO 1412905-18-0 is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal alkyne and a thiol group, separated by a triethylene glycol spacer. This compound is a critical building block in bioconjugation and materials science, enabling the site-specific coupling of biomolecules, polymers, and surfaces via orthogonal click chemistry and thiol-based reactions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as drug delivery system development, surface functionalization, and hydrogel synthesis.

Application

• Bioconjugation and ADC Development: Used for linking antibodies, proteins, or peptides to cytotoxic drugs, fluorophores, or other payloads via copper-catalyzed azide-alkyne cycloaddition (CuAAC) and thiol-maleimide chemistry.
• PEGylation and Drug Delivery: Serves as a functional PEG spacer to modify therapeutic proteins, peptides, or nanoparticles, enhancing solubility, stability, and pharmacokinetic profiles.
• Surface Modification and Biosensors: Facilitates the functionalization of gold surfaces, quantum dots, or other nanomaterials with biomolecular probes for diagnostic and sensing applications.
• Hydrogel and Polymer Network Formation: Acts as a crosslinker or functional monomer in the synthesis of smart hydrogels and biocompatible polymers via thiol-ene or thiol-acrylate reactions.
• Chemical Biology Probes: Enables the synthesis of activity-based probes for studying enzyme function or cellular processes through bioorthogonal labeling strategies.
• Material Science and Nanotechnology: Employed to create functional coatings, self-assembled monolayers (SAMs), and hybrid organic-inorganic materials with tailored properties.

Basic Information

Product Name	Hc≡C-Ch2-Peg3-Sh
CAS No.	1412905-18-0
Molecular Formula	C₁₁H₂₀O₃S
Molecular Weight	232.34 g/mol
Synonyms	Propargyl-PEG3-thiol; 3,6,9-Trioxa-11-thia-1-tetradecyne; 1,8-Dimercapto-3,6-dioxaoct-1-yne; Alkyne-PEG3-thiol; Thiol-PEG3-propargyl; Propargyl-PEG3-SH; Heterobifunctional PEG Alkyne Thiol; 11-Mercapto-3,6,9-trioxaundec-1-yne
EINECS	Contact for details

Quality Control

Our Hc≡C-Ch2-Peg3-Sh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and titration for functional group quantification, to ensure it meets the high standards required for research and commercial applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. Due to its thiol and alkyne functionalities, the material is easily oxidized and moisture-sensitive. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Functional Group Assay (Thiol Titration)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.