Description

3-[2-(1,3-Dihydro-1,3-Dioxo-2H-Isoindol-2-Yl)Ethyl]-6-Fluoro-1H-Indole-4-Carboxylic Acid Methyl Ester is a high-purity, fluorinated indole derivative that serves as a critical advanced pharmaceutical intermediate. This compound is valued for its precise molecular architecture, which is essential for constructing complex active pharmaceutical ingredients (APIs) with targeted biological activity. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel fluorinated drug candidates, particularly in oncology and CNS therapeutic areas.
• Proteolysis Targeting Chimera (PROTAC) Development: Used as a component in the linker or warhead design for targeted protein degradation molecules.
• Kinase Inhibitor Synthesis: Serves as a core scaffold or substituent in the development of selective kinase inhibitors due to the indole and phthalimide motifs.
• Chemical Biology Research: Employed as a tool compound or probe for studying enzyme function and protein-ligand interactions in academic and industrial R&D.
• Process Chemistry & Scale-Up: Used in route scouting and optimization studies for the commercial-scale production of complex molecules.
• Custom Synthesis & Contract Manufacturing: A critical material for CDMOs (Contract Development and Manufacturing Organizations) fulfilling custom synthesis projects for client APIs.

Basic Information

Product Name	3-[2-(1,3-Dihydro-1,3-Dioxo-2H-Isoindol-2-Yl)Ethyl]-6-Fluoro-1H-Indole-4-Carboxylic Acid Methyl Ester
CAS No.	1408282-25-6
Molecular Formula	C21H15FN2O4
Molecular Weight	378.36 g/mol
Synonyms	6-Fluoro-3-[2-(1,3-dioxoisoindolin-2-yl)ethyl]-1H-indole-4-carboxylic acid methyl ester; Methyl 6-fluoro-3-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-1H-indole-4-carboxylate; 3-(2-(1,3-Dioxoisoindolin-2-yl)ethyl)-6-fluoro-1H-indole-4-carboxylic acid methyl ester; 1408282-25-6; 6-Fluoro-3-(2-phthalimidoethyl)-1H-indole-4-carboxylic acid methyl ester; CAS 1408282-25-6
EINECS	Contact for details

Quality Control

Our production of 3-[2-(1,3-Dihydro-1,3-Dioxo-2H-Isoindol-2-Yl)Ethyl]-6-Fluoro-1H-Indole-4-Carboxylic Acid Methyl Ester adheres to stringent quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure the material meets the exacting standards required for pharmaceutical R&D and process development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); prolonged exposure to moisture or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.