Description

2-Chloro-6-(2-Methoxyphenyl)Thieno[3,2-D]Pyrimidine-4-Carbonitrile is a high-value heterocyclic building block and advanced pharmaceutical intermediate. This compound matters for its role as a key synthon in the development of novel small molecule therapeutics, particularly kinase inhibitors. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of targeted drug candidates.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of kinase inhibitor drug candidates targeting various oncology and inflammatory pathways.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its versatile thienopyrimidine scaffold.
• Chemical Biology Probes: Serves as a core structure for developing selective chemical probes to study specific enzyme functions and cellular signaling.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and cGMP manufacturing of active pharmaceutical ingredients (APIs).
• Contract Research & Development (CRO/CMO): Essential material for external research partners and manufacturing organizations supporting drug discovery pipelines.

Basic Information

Product Name	2-Chloro-6-(2-Methoxyphenyl)Thieno[3,2-D]Pyrimidine-4-Carbonitrile
CAS No.	1407180-82-8
Molecular Formula	C15H8ClN3OS
Molecular Weight	313.76 g/mol
Synonyms	2-Chloro-6-(2-methoxyphenyl)thieno[3,2-d]pyrimidine-4-carbonitrile; 4-Cyano-2-chloro-6-(2-methoxyphenyl)thieno[3,2-d]pyrimidine; Thieno[3,2-d]pyrimidine-4-carbonitrile, 2-chloro-6-(2-methoxyphenyl)-; 1407180-82-8; 2-Chloro-6-(o-methoxyphenyl)thieno[3,2-d]pyrimidine-4-carbonitrile
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-(2-Methoxyphenyl)Thieno[3,2-D]Pyrimidine-4-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storage under inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.