Description

2'-Ara-2'-F-2'-Dg Phosphoramidite is a high-purity, modified nucleoside phosphoramidite building block essential for oligonucleotide synthesis. This compound is critical for introducing specific sugar modifications into synthetic DNA/RNA strands, enabling advanced research and therapeutic development. It is primarily used by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics.

Application

• Synthesis of modified antisense oligonucleotides (ASOs) for therapeutic applications.
• Building block for research-grade siRNA and miRNA constructs with enhanced stability.
• Key reagent in the development of oligonucleotide probes for diagnostic assays.
• Production of aptamers with specific binding properties for target validation studies.
• Critical component in solid-phase oligonucleotide synthesis for fundamental biochemical research.
• Manufacturing of oligonucleotides for use in next-generation sequencing (NGS) platforms.
• Development of nucleic acid analogs for studying structure-activity relationships (SAR).

Basic Information

Product Name	2'-Ara-2'-F-2'-Dg Phosphoramidite
CAS No.	1404463-20-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2'-Fluoro-2'-deoxy-2'-arabino-guanosine Phosphoramidite; 2'-F-ara-G Phosphoramidite; 2'-Fluoro-arabinoguanosine Phosphoramidite; 2'-Deoxy-2'-fluoro-arabinoguanosine 3'-phosphoramidite; 2'-F-2'-ara-G Phosphoramidite; Guanosine, 2'-deoxy-2'-fluoro-arabino-, 3'-(2-cyanoethyl diisopropylphosphoramidite)
EINECS	Contact for details

Quality Control

Our 2'-Ara-2'-F-2'-Dg Phosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements for therapeutic development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. Due to its hygroscopic and moisture-sensitive nature, the product should be handled in a controlled, dry atmosphere and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Moisture (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.