Description

n-Trideuteromethyloxetan-3-Amine is a deuterated building block of significant interest in pharmaceutical and agrochemical research. This compound, with CAS number 1403767-20-3, is valued for its role in the synthesis of isotopically labeled molecules, which are crucial for drug metabolism and pharmacokinetic (DMPK) studies. It is primarily utilized by research scientists and process chemists in the pharmaceutical, biotechnology, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A key synthon for incorporating a deuterated methylaminooxetane moiety into active pharmaceutical ingredients (APIs) to study metabolic stability.
• Isotope Labeling: Used in the synthesis of deuterium-labeled compounds for use as internal standards in Liquid Chromatography-Mass Spectrometry (LC-MS) bioanalytical methods.
• Metabolic Research: Enables the creation of deuterated drug candidates to investigate the deuterium kinetic isotope effect (DKIE) and potentially improve pharmacokinetic profiles.
• Agrochemical Development: Serves as a building block for novel, labeled agrochemicals to support environmental fate and metabolism studies.
• Material Science: Potential precursor for specialized polymers or ligands where the deuterated group imparts unique physical or spectroscopic properties.

Basic Information

Product Name	n-Trideuteromethyloxetan-3-Amine
CAS No.	1403767-20-3
Molecular Formula	C4H6D3NO
Molecular Weight	90.14 g/mol
Synonyms	3-Amino-3-(trideuteromethyl)oxetane; (Trideuteromethyl)oxetan-3-amine; Oxetan-3-amine, 3-(trideuteromethyl)-; 3-(Trideuteromethyl)-3-oxetanamine; Deuterated Oxetane Amine; CD3-Oxetane-3-amine; 1403767-20-3; 3-(Aminomethyl-d3)oxetane
EINECS	Contact for details

Quality Control

Every batch of n-Trideuteromethyloxetan-3-Amine is produced and analyzed under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles to ensure consistency for your critical research and development applications. Our quality systems are designed to support cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.