Description

2-Fmoc-5-Oxo-Octahydro-Isoindole-1-Carboxylic Acid is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block for constructing complex peptide chains, offering precise control over molecular architecture. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers in the development of novel therapeutic peptides and peptidomimetics, where its unique fused bicyclic structure introduces conformational constraints.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the controlled assembly of peptides, particularly those requiring constrained amino acid analogs.
• Peptidomimetic Drug Discovery: Used to incorporate rigid, bicyclic structural motifs into peptide backbones to enhance metabolic stability, bioavailability, and target binding affinity.
• Combinatorial Chemistry Libraries: Serves as a valuable scaffold for generating diverse libraries of conformationally restricted compounds for high-throughput screening.
• Research & Development: Employed in academic and industrial R&D for studying structure-activity relationships (SAR) in bioactive peptides.
• API Intermediate: Functions as a sophisticated intermediate in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) with peptide components.

Basic Information

Product Name	2-Fmoc-5-Oxo-Octahydro-Isoindole-1-Carboxylic Acid
CAS No.	1403766-50-6
Molecular Formula	C24H23NO5
Molecular Weight	405.44 g/mol
Synonyms	1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-oxooctahydro-1H-isoindole-2-carboxylic acid; Fmoc-5-oxo-octahydroisoindole-1-carboxylic acid; 2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-5-oxooctahydro-1H-isoindole-1-carboxylic acid; 1-N-Fmoc-5-oxo-octahydroisoindole-2-carboxylic Acid; (1S,3aR,7aS)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-5-oxooctahydro-1H-isoindole-2-carboxylic Acid; Fmoc-D-Octahydroindole-2-carboxylic acid derivative
EINECS	Contact for details

Quality Control

Every batch of 2-Fmoc-5-Oxo-Octahydro-Isoindole-1-Carboxylic Acid is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent batch-to-batch quality suitable for sensitive pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.