Description

(1R,4R)-2-Methyl-2,5-Diaza-Bicyclo[2.2.1]Heptane Dihydrochloride is a high-purity, chiral bicyclic diamine salt of significant interest in advanced organic synthesis. This compound serves as a critical and versatile chiral building block for the development of novel pharmaceutical agents and complex molecular architectures. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce rigid, three-dimensional scaffolds with defined stereochemistry into their target molecules.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets and receptor modulators.
• Ligand Synthesis: Used to construct sophisticated chiral ligands for asymmetric catalysis, enabling enantioselective transformations.
• Molecular Scaffold: Its rigid, bicyclic structure makes it an ideal scaffold in medicinal chemistry for probing structure-activity relationships (SAR) and improving metabolic stability.
• Agrochemical Research: Employed in the development of new chiral herbicides, fungicides, and plant growth regulators.
• Chemical Biology Probes: Useful for creating tagged molecular probes to study biological pathways and enzyme functions.
• Academic & Contract Research: A valuable reagent for universities and CROs conducting research in synthetic methodology and novel compound libraries.

Basic Information

Product Name	(1R,4R)-2-Methyl-2,5-Diaza-Bicyclo[2.2.1]Heptane Dihydrochloride
CAS No.	1403763-25-6
Molecular Formula	C7H16Cl2N2
Molecular Weight	199.12 g/mol
Synonyms	(1R,4R)-2-Methyl-2,5-diazabicyclo[2.2.1]heptane dihydrochloride; (1R,4R)-2-Methyl-2,5-diazabicyclo[2.2.1]heptane hydrochloride; 2-Methyl-2,5-diazabicyclo[2.2.1]heptane dihydrochloride, (1R,4R)-; endo-2-Methyl-2,5-diazabicyclo[2.2.1]heptane dihydrochloride; (1R,4R)-endo-2-Methyl-2,5-diazabicyclo[2.2.1]heptane dihydrochloride; Bicyclo[2.2.1]heptane, 2-methyl-2,5-diaza-, dihydrochloride, (1R,4R)-; (1R,4R)-2-Methyl-2,5-DABCO dihydrochloride
EINECS	Contact for details

Quality Control

Our (1R,4R)-2-Methyl-2,5-Diaza-Bicyclo[2.2.1]Heptane Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.