Description

3-(Trifluoromethyl)Oxetan-3-Ol CAS NO 1403676-72-1 is a high-value, fluorinated oxetane building block prized for its unique chemical structure, which combines a strained oxetane ring with a potent trifluoromethyl group. This compound is essential for introducing trifluoromethylated, polar, and three-dimensional motifs into target molecules, significantly influencing their physicochemical properties. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for applications in medicinal chemistry, crop protection, and polymer science.

Application

• Pharmaceutical Intermediate: A key synthon for incorporating the CF3-oxetane pharmacophore into drug candidates to modulate lipophilicity, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Advanced Material Monomer: Serves as a functional monomer for synthesizing specialty polymers and coatings with tailored surface properties, chemical resistance, and optical characteristics.
• Ligand and Catalyst Development: Employed in organometallic chemistry and catalysis as a building block for creating novel chiral ligands and catalysts.
• Fluorine Chemistry Research: A versatile reagent for academic and industrial research exploring new fluorination methodologies and the synthesis of complex fluorinated architectures.
• Liquid Crystal and Electronic Materials: Potential use in the synthesis of components for electronic displays and organic semiconductors due to its polar and steric profile.

Basic Information

Product Name	3-(Trifluoromethyl)Oxetan-3-Ol
CAS No.	1403676-72-1
Molecular Formula	C4H5F3O2
Molecular Weight	142.08 g/mol
Synonyms	3-(Trifluoromethyl)-3-oxetanol; 3-Hydroxy-3-(trifluoromethyl)oxetane; 3-Oxetanol, 3-(trifluoromethyl)-; α-(Trifluoromethyl)-β-hydroxyoxetane; Oxetan-3-ol, 3-(trifluoromethyl)-; TFMO; 3-Trifluoromethyloxetan-3-ol
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)Oxetan-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.