Description

3-Bromo-2-(Difluoromethyl)Thiophene is a high-value, multi-functional heterocyclic building block designed for advanced organic synthesis. This compound is critical for introducing the unique thiophene-difluoromethyl-bromo pharmacophore into target molecules, enabling the fine-tuning of electronic properties, lipophilicity, and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and CNS-targeted drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the difluoromethyl group enhances bioactivity and environmental stability.
• Material Science Precursor: Serves as a monomer or building block for conjugated polymers and organic electronic materials, such as OLEDs and organic semiconductors.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: An essential reagent for studying structure-activity relationships (SAR) and introducing fluorine atoms into complex molecules.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development candidates at various scales.

Basic Information

Product Name	3-Bromo-2-(Difluoromethyl)Thiophene
CAS No.	1403667-53-7
Molecular Formula	C5H3BrF2S
Molecular Weight	213.04 g/mol
Synonyms	3-Bromo-2-(difluoromethyl)thiophene; 2-(Difluoromethyl)-3-bromothiophene; Thiophene, 3-bromo-2-(difluoromethyl)-; 1403667-53-7; 3-Bromo-2-difluoromethylthiophene
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-2-(Difluoromethyl)Thiophene is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request and are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.