Description

2-(5-Cyclohexylthiophen-2-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. This compound matters because it serves as a critical intermediate in cross-coupling reactions, enabling the efficient construction of complex organic molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl/heteroaryl halides and this boronic ester, crucial for constructing biaryl motifs in drug discovery.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those containing functionalized thiophene and cyclohexyl moieties.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Organic Electronic Materials: Serves as a precursor for synthesizing conjugated polymers and small molecules used in OLEDs, organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Ligand and Catalyst Development: Utilized to create novel ligands for transition metal catalysis or as a functional handle in metal-organic frameworks (MOFs).
• Chemical Biology & Probe Development: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes for imaging and diagnostic applications.

Basic Information

Product Name	2-(5-Cyclohexylthiophen-2-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1402166-55-5
Molecular Formula	C₁₆H₂₅BO₂S
Molecular Weight	292.24 g/mol
Synonyms	5-Cyclohexyl-2-thiopheneboronic acid pinacol ester; 2-(5-Cyclohexyl-2-thienyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Cyclohexylthiophene-2-boronic acid pinacol ester; (5-Cyclohexylthiophen-2-yl)boronic acid pinacol ester; 2-(5-Cyclohexylthiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol 5-Cyclohexyl-2-thienylboronate; 5-Cyclohexyl-2-thienylboronic Acid Pinacol Ester
EINECS	Contact for details

Quality Control

Our 2-(5-Cyclohexylthiophen-2-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a desiccator to minimize exposure to moisture and oxygen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.