Description

2-Amino-7-(Boc-Methyl-Amino)-5-Fluoro-1H-Indole-3-Carboxylic Acid Ethyl Ester is a sophisticated, multi-functional indole derivative designed for advanced organic synthesis. This compound is a critical building block in medicinal chemistry, valued for its protected amine and carboxylic ester functionalities which enable precise molecular construction. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis professionals for developing novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially kinase inhibitors and receptor modulators.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile reactive sites.
• Peptidomimetic Synthesis: Serves as a constrained amino acid analog for constructing novel peptide-like molecules.
• Fluorinated Compound Libraries: Essential for creating focused screening libraries that explore the benefits of fluorine substitution in bioactive molecules.
• Boc-Protected Amine Chemistry: Provides a handle for selective deprotection and further functionalization in multi-step synthetic routes.
• API Process Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material production.

Basic Information

Product Name	2-Amino-7-(Boc-Methyl-Amino)-5-Fluoro-1H-Indole-3-Carboxylic Acid Ethyl Ester
CAS No.	1400808-16-3
Molecular Formula	C₁₈H₂₄FN₃O₄
Molecular Weight	365.40 g/mol
Synonyms	Ethyl 2-Amino-7-[(tert-butoxycarbonyl)(methyl)amino]-5-fluoro-1H-indole-3-carboxylate; 5-Fluoro-2-amino-7-[(N-Boc-N-methyl)amino]-1H-indole-3-carboxylic Acid Ethyl Ester; 2-Amino-7-[(tert-butoxycarbonyl)(methyl)amino]-5-fluoro-1H-indole-3-carboxylic Acid Ethyl Ester; 1400808-16-3; BOC-Methyl-Amino-Fluoro-Indole Ethyl Ester; tert-Butyl (7-Amino-5-fluoro-3-(ethoxycarbonyl)-1H-indol-2-yl)(methyl)carbamate
EINECS	Contact for details

Quality Control

Our 2-Amino-7-(Boc-Methyl-Amino)-5-Fluoro-1H-Indole-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with complete analytical data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.