Description

(1R,4R,5R)-tert-Butyl 5-Amino-2-Azabicyclo[2.2.1]Heptane-2-Carboxylate (Wx120469) is a high-purity, chiral bicyclic amine building block of significant interest in advanced pharmaceutical synthesis. Its rigid, three-dimensional structure and protected amine functionality make it a valuable scaffold for constructing complex molecules with precise stereochemistry. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly in areas requiring sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and antiviral research.
• Asymmetric Synthesis: Serves as a precursor or catalyst ligand in stereoselective chemical reactions due to its defined (1R,4R,5R) configuration.
• Peptidomimetics & PROTACs: Used to construct conformationally restricted peptide analogs and linkers for proteolysis-targeting chimeras (PROTACs).
• Chemical Biology Probes: Employed in the development of molecular probes for studying enzyme function and biological pathways.
• Agrochemical Research: Potential intermediate in the discovery of new, enantiomerically pure agrochemicals.
• Academic & Process Chemistry: Used in methodological development and scale-up studies for complex organic molecule production.

Basic Information

Product Name	(1R,4R,5R)-tert-Butyl 5-Amino-2-Azabicyclo[2.2.1]Heptane-2-Carboxylate (Wx120469)
CAS No.	1400808-02-7
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	(1R,4R,5R)-2-(tert-Butoxycarbonyl)-2,5-diazabicyclo[2.2.1]heptane; (1R,4R,5R)-5-Amino-2-((tert-butoxy)carbonyl)-2-azabicyclo[2.2.1]heptane; (1R,4R,5R)-N-Boc-2,5-diazabicyclo[2.2.1]heptane; tert-Butyl (1R,4R,5R)-5-amino-2-azabicyclo[2.2.1]heptane-2-carboxylate; (1R,4R,5R)-Boc-2,5-Diazabicyclo[2.2.1]heptane; WX-120469; Wx120469; (1R,4R,5R)-5-Amino-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (1R,4R,5R)-tert-Butyl 5-Amino-2-Azabicyclo[2.2.1]Heptane-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding research and development applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and compliance with customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.