Description

(R)-Praziquantel-D11 is a deuterium-labeled stereoisomer of the anthelmintic drug praziquantel, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is critical for ensuring the accuracy and reliability of quantitative mass spectrometry analyses in pharmaceutical research and development. It is primarily utilized by analytical laboratories, CROs, and pharmaceutical companies engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and quality control testing.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the precise quantification of praziquantel and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism Studies (DMPK): Enables accurate tracking of the parent drug's absorption, distribution, metabolism, and excretion (ADME) profile in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Used to develop, optimize, and validate robust high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) methods compliant with FDA and EMA guidelines.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling: Provides essential data for modeling drug concentration-time relationships, supporting dose optimization and efficacy studies.
• Stability-Indicating Assays: Employed in assays to monitor the stability of praziquantel in pharmaceutical formulations under various stress conditions.
• Veterinary Pharmaceutical Analysis: Supports residue testing and pharmacokinetic studies of praziquantel in veterinary medicine.

Basic Information

Product Name	(R)-Praziquantel-D11
CAS No.	1399880-38-6
Molecular Formula	C19H13D11N2O2
Molecular Weight	~ 329.45 g/mol
Synonyms	(R)-2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one-d11; (R)-Praziquantel D11; (R)-Biltricide-D11; (R)-PZQ-D11; Deuterated (R)-Praziquantel; (11R)-Praziquantel-d11; (R)-2-(Cyclohexanecarbonyl)decahydro-2H-pyrazino[2,1-a]isoquinolin-4-one-d11; EMBAY 8440-d11
EINECS	Contact for details

Quality Control

Every batch of (R)-Praziquantel-D11 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including assay, chiral purity, isotopic enrichment (D11), and identification. A detailed Certificate of Analysis (COA) providing batch-specific data from advanced analytical techniques (HPLC, MS, NMR) is supplied with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R-isomer)
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.