Description

(S)-3-Amino(Piperidine-3-D1)-2,6-Dione Hydrochloride CAS NO 1398112-31-6 is a high-purity, deuterated piperidine derivative used as a critical building block in advanced pharmaceutical research and development. This compound is specifically valued for its role in the synthesis of novel active pharmaceutical ingredients (APIs), where its deuterium-labeled structure can significantly influence metabolic stability and pharmacokinetic profiles. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and contract research sectors for drug discovery programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of deuterated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Isotope Labeling Agent: Used in the preparation of deuterium-labeled compounds for metabolism studies (DMPK) and internal standards for bioanalytical mass spectrometry.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of complex, high-value target molecules.
• Academic Research: Used in university and institutional labs for studying reaction mechanisms and developing new synthetic methodologies involving chiral amines and deuterium chemistry.

Basic Information

Product Name	(S)-3-Amino(Piperidine-3-D1)-2,6-Dione Hydrochloride
CAS No.	1398112-31-6
Molecular Formula	C6H10DClN3O2
Molecular Weight	191.63 g/mol
Synonyms	(3S)-3-Amino-3-deuteriopiperidine-2,6-dione hydrochloride; (S)-3-Amino-3-deuterioglutarimide hydrochloride; (S)-3-Amino-3-deuteriopiperidine-2,6-dione HCl; 3-Deutero-3-aminoglutarimide hydrochloride (S-form); 3-Amino-3-deuterio-2,6-piperidinedione hydrochloride, (S)-; Deuterated Thalidomide metabolite derivative; (S)-Aminoglutarimide-3-d hydrochloride; 1398112-31-6
EINECS	Contact for details

Quality Control

Our (S)-3-Amino(Piperidine-3-D1)-2,6-Dione Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, isotopic enrichment analysis, and impurity profiling to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are provided to guarantee traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Deuterium Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.