Description

Urapidil-D3 (Methoxy-D3) is a stable isotope-labeled analog of the antihypertensive agent urapidil, specifically deuterated at the methoxy position. This high-purity reference standard is essential for ensuring the accuracy and reliability of quantitative analytical methods. It is primarily used by pharmaceutical research and development laboratories, clinical testing facilities, and manufacturers of analytical standards for applications in pharmacokinetics, metabolism studies, and quality control.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of urapidil in biological matrices (e.g., plasma, serum) using liquid chromatography-tandem mass spectrometry.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in mass spectrometry-based studies to trace drug absorption, distribution, metabolism, and excretion (ADME) pathways.
• Bioanalytical Method Development and Validation: A key component in developing and validating robust, GLP-compliant analytical methods for clinical and preclinical trials.
• Pharmaceutical Quality Control: Employed as a certified reference material (CRM) to assay the active pharmaceutical ingredient (API) and ensure batch-to-batch consistency.
• Forensic and Clinical Toxicology: Facilitates accurate identification and quantification of urapidil in complex samples for diagnostic or forensic purposes.

Basic Information

Product Name	Urapidil-D3 (Methoxy-D3)
CAS No.	1398066-08-4
Molecular Formula	C₂₀H₂₆D₃N₅O₃
Molecular Weight	Contact for details
Synonyms	6-({3-[4-(2-Methoxyphenyl)piperazin-1-yl]propyl}amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione (Methoxy-D3); Urapidil-d3; Urapidil (methoxy-d3); 1,3-Dimethyl-6-({3-[4-(o-methoxy-d3-phenyl)-1-piperazinyl]propyl}amino)-2,4(1H,3H)-pyrimidinedione; Ebrantil-D3
EINECS	Contact for details

Quality Control

Our Urapidil-D3 (Methoxy-D3) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C) and high-resolution mass spectrometry (HRMS) for structural confirmation and isotopic enrichment verification. Purity is determined via HPLC and chemical purity assays. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.