Description

3-(3-Ethoxy-4-Methoxyphenyl)Propionic-2,2,3,3-D4 Acid is a high-purity, deuterium-labeled derivative of a key phenylpropionic acid intermediate. This compound matters for its critical role as an internal standard in quantitative mass spectrometry, enabling precise and reliable analytical measurements in complex matrices. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers for drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and impurity profiling.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of the non-deuterated parent compound and related metabolites in biological samples (plasma, serum, urine).
• Pharmaceutical Research: Used in drug discovery and development for pharmacokinetic (PK) and pharmacodynamic (PD) studies to track drug absorption, distribution, metabolism, and excretion (ADME).
• Metabolite Identification & Profiling: Aids in the identification and structural elucidation of drug metabolites using high-resolution mass spectrometry.
• Stable Isotope Labeling Studies: Serves as a tracer in mechanistic studies of metabolic pathways and chemical reaction mechanisms.
• Analytical Method Validation: Critical for developing, validating, and transferring GLP/GMP-compliant bioanalytical methods.
• Impurity Reference Standard: Can be used as a reference marker for process-related impurities or degradation products in active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	3-(3-Ethoxy-4-Methoxyphenyl)Propionic-2,2,3,3-D4 Acid
CAS No.	1398065-51-4
Molecular Formula	C₁₂H₁₂D₄O₄
Molecular Weight	228.27 g/mol
Synonyms	3-(3-Ethoxy-4-methoxyphenyl)propionic-2,2,3,3-d4 acid; 2,2,3,3-Tetradeutero-3-(3-ethoxy-4-methoxyphenyl)propanoic acid; 3-(3-Ethoxy-4-methoxyphenyl)propanoic-2,2,3,3-d4 acid; Deuterated 3-(3-Ethoxy-4-methoxyphenyl)propionic acid; D4-3-(3-Ethoxy-4-methoxyphenyl)propionic acid; 3-(3-Ethoxy-4-Methoxyphenyl)Propionic Acid-d4; [2,2,3,3-²H₄]-3-(3-Ethoxy-4-methoxyphenyl)propanoic acid
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is produced and tested under strict quality management protocols. We provide comprehensive analytical data to ensure high isotopic purity and chemical purity, critical for reliable analytical results. Certificates of Analysis (COA) are supplied with each shipment, detailing results for isotopic enrichment (D%), chemical purity (by HPLC), and identity confirmation (by NMR and MS). Our quality systems support compliance with the standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.