Description

Thio-Peg2-T-Butyl Ester is a specialized bifunctional PEG derivative featuring a thiol group and a protected carboxylic acid terminus. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the controlled attachment of molecules via thiol-maleimide or thiol-halogen click chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for creating stable, functionalized linkers in drug delivery systems, diagnostic probes, and polymer chemistry.

Application

• Bioconjugation Reagent: Used for site-specific protein and antibody labeling, particularly in ADC (Antibody-Drug Conjugate) development.
• Pharmaceutical Intermediate: Serves as a key linker in the synthesis of prodrugs and targeted therapeutic agents.
• Polymer Modification: Functionalizes polymer backbones to introduce thiol-reactive sites for further cross-linking or surface grafting.
• Diagnostic Probe Synthesis: Facilitates the attachment of fluorescent dyes or other reporter molecules to targeting ligands.
• Surface Functionalization: Used to create self-assembled monolayers (SAMs) on gold or other surfaces for biosensor applications.
• Hydrogel Formation: Acts as a cross-linking agent in the preparation of PEG-based hydrogels for tissue engineering and controlled release.

Basic Information

Product Name	Thio-Peg2-T-Butyl Ester
CAS No.	1398044-50-2
Molecular Formula	C13H26O5S
Molecular Weight	294.41 g/mol
Synonyms	1,8-Dimercapto-3,6-dioxaoctane-8-carboxylic Acid tert-Butyl Ester; 2,2-Dimethyl-4-oxo-3,8,11-trioxa-5-thia-2-silatetradecan-14-oic Acid tert-Butyl Ester (Silanated); tert-Butyl 3,6,9-trioxa-12-thiadodecan-12-oate; HS-PEG2-COOtBu; Thiol-PEG2-t-butyl ester; SH-PEG2-t-butyl ester; 3,6-Dioxa-8-thiaoctanoic acid, 8-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our Thio-Peg2-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. The product is easily oxidized and moisture-sensitive; allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.