Description

3-(3,5-Difluorophenyl)Oxetan-3-Ol is a high-value oxetane derivative and a versatile chiral building block in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of novel pharmaceuticals and agrochemicals, particularly where the oxetane ring is used to modulate physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require fluorinated aromatic systems.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique thermal or optical properties.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a molecular scaffold in probe design.
• Academic and Industrial R&D: Fundamental research reagent for exploring new organic reactions and methodologies involving oxetane chemistry.

Basic Information

Product Name	3-(3,5-Difluorophenyl)Oxetan-3-Ol
CAS No.	1395281-64-7
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	3-(3,5-Difluorophenyl)-3-hydroxyoxetane; 3-Hydroxy-3-(3,5-difluorophenyl)oxetane; Oxetan-3-ol, 3-(3,5-difluorophenyl)-; 1395281-64-7; 3-(3,5-Difluorophenyl)oxetan-3-ol; 3,5-Difluoro-α-(2-hydroxyethyl)benzenemethanol (tautomeric form)
EINECS	Contact for details

Quality Control

Our 3-(3,5-Difluorophenyl)Oxetan-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for water content, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.