Description

(R)-2-((tert-Butyldimethylsilyl)Oxy)-1-(4-Chloro-3-Fluorophenyl)Ethanol is a high-purity chiral intermediate of significant importance in modern synthetic chemistry. Its value lies in its role as a key building block for the enantioselective synthesis of complex, biologically active molecules. This compound is primarily needed by pharmaceutical R&D and process chemistry teams for the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereochemical complexity with high enantiomeric purity.
• API Manufacturing: Serves as a building block in the multi-step synthesis of target Active Pharmaceutical Ingredients (APIs), leveraging its protected alcohol and chiral center.
• Process Chemistry & Scale-up: Employed in route scouting, optimization, and pilot-scale production for new chemical entities (NCEs).
• Agrochemical Research: Potential application in the synthesis of chiral agrochemicals, such as herbicides or fungicides, where specific stereochemistry impacts biological activity.
• Academic & Institutional Research: Used in universities and research institutes for methodological studies in organic synthesis and catalysis.

Basic Information

Product Name	(R)-2-((tert-Butyldimethylsilyl)Oxy)-1-(4-Chloro-3-Fluorophenyl)Ethanol
CAS No.	1395078-43-9
Molecular Formula	C14H22ClFO2Si
Molecular Weight	304.86 g/mol
Synonyms	(R)-1-(4-Chloro-3-fluorophenyl)-2-((tert-butyldimethylsilyl)oxy)ethanol; (R)-2-(tert-Butyldimethylsilyloxy)-1-(4-chloro-3-fluorophenyl)ethanol; (R)-TBDMS Protected 4-Chloro-3-fluorophenylethanol; (1R)-1-(4-Chloro-3-fluorophenyl)-2-[(1,1-dimethylethyl)dimethylsilyl]oxy]ethanol; (R)-1-(4-Chloro-3-fluorophenyl)-2-((TBDMSO)ethanol; (R)-TBDMS ether of 1-(4-Chloro-3-fluorophenyl)ethanol; (R)-2-(Tert-butyldimethylsiloxy)-1-(4-chloro-3-fluorophenyl)ethan-1-ol
EINECS	Contact for details

Quality Control

Our (R)-2-((tert-Butyldimethylsilyl)Oxy)-1-(4-Chloro-3-Fluorophenyl)Ethanol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for advanced synthetic applications. All products undergo rigorous analytical testing, including chiral HPLC to confirm enantiomeric excess (ee) and standard purity assays. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.