Description

7,8-Difluoro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is a high-purity, fluorinated heterocyclic building block essential for modern pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets. It is primarily utilized by R&D chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors seeking to incorporate its unique difluorinated tetrahydroisoquinoline scaffold.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, especially in CNS disorders and oncology.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry & Scale-up: Serves as a starting material or advanced intermediate for the kilogram-scale synthesis of target molecules under GMP conditions.
• Agrochemical Development: Employed in the research of novel pesticides and herbicides, leveraging the biological activity of the fluorinated isoquinoline core.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects.

Basic Information

Product Name	7,8-Difluoro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
CAS No.	1394662-70-4
Molecular Formula	C9H8F2N•HCl
Molecular Weight	203.62 g/mol (Free base: 167.16 g/mol)
Synonyms	7,8-Difluoro-1,2,3,4-tetrahydroisoquinoline HCl; 7,8-Difluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride; 1,2,3,4-Tetrahydro-7,8-difluoro-isoquinoline hydrochloride; 7,8-Difluoro-1,2,3,4-THQ•HCl; 7,8-Difluoro-THIQ hydrochloride
EINECS	Contact for details

Quality Control

Our 7,8-Difluoro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment supports applications requiring research-grade to cGMP standards for early-phase clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.