Description

1-Cyclopropyl-2,4-Difluorobenzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the cyclopropyl and difluoro motifs are critical for modulating biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries seeking to introduce steric and electronic complexity into target molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-infective therapies.
• Agrochemical Synthesis: Serves as a key precursor in the development of next-generation herbicides, fungicides, and insecticides, where the fluorinated cyclopropyl group enhances metabolic stability and bioavailability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis, enabling novel cross-coupling and functionalization reactions.
• Material Science Research: Employed in the synthesis of fluorinated liquid crystals, organic semiconductors, and polymers with tailored electronic and surface properties.
• Chemical Biology Probes: Acts as a scaffold for creating fluorescent tags and molecular probes used in biochemical assay development and diagnostic applications.

Basic Information

Product Name	1-Cyclopropyl-2,4-Difluorobenzene
CAS No.	1394291-34-9
Molecular Formula	C9H8F2
Molecular Weight	154.16 g/mol
Synonyms	2,4-Difluoro-1-cyclopropylbenzene; 1-Cyclopropyl-2,4-difluorobenzene; Benzene, 1-cyclopropyl-2,4-difluoro-; (2,4-Difluorophenyl)cyclopropane; 2,4-Difluorocyclopropylbenzene; Cyclopropyl(2,4-difluorophenyl)methane
EINECS	Contact for details

Quality Control

Our 1-Cyclopropyl-2,4-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.