Description

1-[[2-Bromo-5-(Trifluoromethyl)Phenyl]Methyl]-Pyrrolidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated and trifluoromethylated aromatic structure. This compound is of significant commercial interest for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily utilized by pharmaceutical R&D laboratories, process chemistry teams, and fine chemical manufacturers seeking reliable, high-quality building blocks for complex molecule construction.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of potential drug candidates, especially those targeting neurological disorders and cancer.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities with improved potency and pharmacokinetic profiles.
• Process Development: Serves as a key starting material (KSM) or intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Agrochemical Synthesis: May be employed in the development of advanced crop protection agents, leveraging the biological activity of the trifluoromethyl and bromo substituents.
• Ligand and Catalyst Development: The pyrrolidine moiety can be utilized in the design of novel chiral ligands or organocatalysts for asymmetric synthesis.

Basic Information

Product Name	1-[[2-Bromo-5-(Trifluoromethyl)Phenyl]Methyl]-Pyrrolidine Hydrochloride
CAS No.	1394291-33-8
Molecular Formula	C12H12BrF3N·HCl
Molecular Weight	334.59 g/mol (Free base: 298.13 g/mol)
Synonyms	1-[(2-Bromo-5-(trifluoromethyl)benzyl)]pyrrolidine hydrochloride; 1-((2-Bromo-5-(trifluoromethyl)phenyl)methyl)pyrrolidine HCl; 2-Bromo-α-(pyrrolidin-1-ylmethyl)-α,α,α-trifluorotoluene hydrochloride; (2-Bromo-5-(trifluoromethyl)benzyl)pyrrolidine hydrochloride; Pyrrolidine, 1-[[2-bromo-5-(trifluoromethyl)phenyl]methyl]-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our production of 1-[[2-Bromo-5-(Trifluoromethyl)Phenyl]Methyl]-Pyrrolidine Hydrochloride adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.