Description

5-Methoxytryptamine-α,α,β,β-D4 Hcl is a deuterated analog of the endogenous neurotransmitter 5-methoxytryptamine, specifically labeled at four positions. This compound is of significant value as a stable isotope-labeled internal standard for quantitative mass spectrometry, ensuring high accuracy and reliability in analytical measurements. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, metabolic profiling, and neurochemical research.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of 5-methoxytryptamine and related indoleamines in complex biological matrices like plasma, serum, and tissue homogenates.
• Metabolomics and Biomarker Discovery: Used in high-throughput screening to identify and quantify tryptamine pathway metabolites for disease research.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the fate of drug candidates and their metabolites.
• Neurochemical Research: Facilitates the study of serotonin and melatonin pathway dynamics, receptor binding assays, and enzymatic activity.
• Quality Control in API Manufacturing: Serves as a reference standard in the quality control of active pharmaceutical ingredients (APIs) and finished drug products.
• Forensic and Clinical Toxicology: Aids in the accurate detection and measurement of psychoactive tryptamines and their metabolites.

Basic Information

Item	Details
Product Name	5-Methoxytryptamine-α,α,β,β-D4 Hcl
CAS No.	1394230-20-6
Molecular Formula	C₁₁H₁₀D₄N₂O•HCl
Molecular Weight	226.75 g/mol (for free base C₁₁H₁₀D₄N₂O)
Synonyms	5-Methoxy-D4-tryptamine hydrochloride; 5-MeO-D4-Tryptamine HCl; 2-(5-Methoxy-1H-indol-3-yl)ethan-1,1,2,2-d4-amine hydrochloride; 5-Methoxytryptamine-d4 HCl; 3-(2-Aminoethyl)-5-methoxyindole-α,α,β,β-d4 hydrochloride; Deuterated 5-Methoxytryptamine HCl; 5-MT-d4 HCl
EINECS	Contact for details

Quality Control

Every batch of 5-Methoxytryptamine-α,α,β,β-D4 Hcl is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment meet the stringent requirements for research and diagnostic use. Our quality system ensures traceability and compliance with relevant standards. A comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic purity, chemical purity, and residual solvents is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.