Description

3-Chloro-8-Fluoroisoquinoline is a high-purity, multi-functional heterocyclic building block essential for modern synthetic chemistry. Its unique halogenated isoquinoline structure makes it a critical intermediate for constructing complex molecules with tailored biological and physical properties. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for applications in drug discovery and advanced material science.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and pesticides, leveraging its halogenated ring system for bioactivity.
• Material Science: Acts as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient aromatic system.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology: Utilized as a probe or tag in biochemical research to study enzyme mechanisms and protein interactions.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.

Basic Information

Product Name	3-Chloro-8-Fluoroisoquinoline
CAS No.	1394003-78-1
Molecular Formula	C9H5ClFN
Molecular Weight	181.59 g/mol
Synonyms	8-Fluoro-3-chloroisoquinoline; 3-Chloro-8-fluoro-isoquinoline; Isoquinoline, 3-chloro-8-fluoro-; 1394003-78-1; 3-Chloro-8-fluoroisoquinoline; 8-Fluoro-3-chloro-isoquinoline
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-8-Fluoroisoquinoline is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC-MS, and NMR to ensure identity, purity, and consistency meet the exacting standards required for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when not in use to prevent degradation and maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.