Description

6-Bromo-3,3-Difluoroindolin-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its halogenated and fluorinated indolinone core structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel, biologically active molecules with enhanced metabolic stability and binding affinity. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel small-molecule drugs, especially kinase inhibitors and targeted cancer therapies.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization campaigns due to its versatile bromo and difluoro substituents.
• Agrochemical Synthesis: Acts as a precursor in the development of new-generation herbicides and pesticides, leveraging its unique heterocyclic scaffold.
• Material Science: Investigated as a monomer or building block for specialty polymers and organic electronic materials.
• Chemical Biology: Employed in the synthesis of molecular probes and tool compounds for studying enzyme function and biological pathways.

Basic Information

Product Name	6-Bromo-3,3-Difluoroindolin-2-One
CAS No.	1393532-37-0
Molecular Formula	C8H4BrF2NO
Molecular Weight	248.03 g/mol
Synonyms	6-Bromo-3,3-difluoro-1,3-dihydro-2H-indol-2-one; 6-Bromo-3,3-difluoroindolin-2-one; 2H-Indol-2-one, 6-bromo-3,3-difluoro-1,3-dihydro-; 1393532-37-0; 6-Bromo-3,3-difluoro-2-indolinone; 3,3-Difluoro-6-bromoindolin-2-one
EINECS	Contact for details

Quality Control

Our 6-Bromo-3,3-Difluoroindolin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.