Description

Bromo-Peg4-Acid CAS NO 1393330-38-5 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a bromoalkyl group and a carboxylic acid terminus. This bifunctional linker is essential for creating stable, cleavable, or functionalized conjugates in advanced bioconjugation and materials science. It is a critical reagent for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries who require precise, reliable, and high-purity building blocks for drug delivery systems, surface modification, and probe development.

Application

• Bioconjugation and ADC Development: Used as a versatile linker for attaching cytotoxic drugs to antibodies in Antibody-Drug Conjugate (ADC) synthesis, leveraging the bromo group for alkylation and the acid for further coupling.
• PEGylation Reagent: Serves as a functional PEG spacer to modify peptides, proteins, and nanoparticles, improving solubility, stability, and pharmacokinetic profiles.
• Polymer and Materials Chemistry: Acts as a monomer or cross-linking agent in the synthesis of functionalized hydrogels, smart materials, and biocompatible coatings.
• Diagnostic Probe Synthesis: Facilitates the construction of imaging probes and biosensors by linking targeting molecules to reporter groups.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a handle for the introduction of PEG chains or functional groups during peptide assembly.
• Surface Functionalization: Used to create reactive interfaces on gold, silica, or polymer surfaces for subsequent biomolecule immobilization.

Basic Information

Product Name	Bromo-Peg4-Acid
CAS No.	1393330-38-5
Molecular Formula	C13H25BrO6
Molecular Weight	357.24 g/mol
Synonyms	15-Bromo-4,7,10,13-tetraoxapentadecanoic acid; 2-[2-[2-[2-(2-Bromoethoxy)ethoxy]ethoxy]ethoxy]acetic acid; Br-PEG4-CH2COOH; Bromo(tetraethylene glycol)acetic acid; Bromo-PEG4-acetic acid; α-Bromo-ω-carboxy tetraethylene glycol; Bromo-PEG4-C2-acid; 1-Bromo-3,6,9,12-tetraoxapentadecan-15-oic acid
EINECS	Contact for details

Quality Control

Our Bromo-Peg4-Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles. Our quality commitment supports applications in GMP-compatible processes and research requiring reliable, traceable materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.