Description

Br-Peg1-Cootbu CAS NO 1393330-36-3 is a specialized bifunctional PEG linker featuring a bromo (Br) head group and a tert-butyl ester (Cootbu) tail, designed for precise bioconjugation and chemical synthesis. This compound is critical for researchers and manufacturers requiring controlled, site-specific modifications in the development of advanced materials and bioactive molecules. It is primarily utilized in the pharmaceutical, biotechnology, and materials science sectors for applications such as PROTAC linker synthesis, peptide modification, and polymer functionalization.

Application

• PROTAC & Bifunctional Molecule Synthesis: Serves as a key linker/spacer for constructing Proteolysis Targeting Chimeras (PROTACs) and other heterobifunctional degraders.
• Peptide & Protein Modification: Enables site-specific PEGylation or functionalization of peptides and proteins to enhance stability, solubility, or pharmacokinetic properties.
• Polymer & Material Science: Acts as a functional monomer or cross-linking agent for creating advanced polymers with tailored properties.
• Bioconjugation Reagent: Used to conjugate small molecules, fluorophores, or drugs to antibodies, nanoparticles, or other biological entities.
• Chemical Intermediate: A versatile building block in organic synthesis for introducing PEG spacers and protected carboxylic acid functionalities.
• ADC Development: Potential use in the synthesis of Antibody-Drug Conjugates (ADCs) as a cleavable or non-cleavable linker component.

Basic Information

Product Name	Br-Peg1-Cootbu
CAS No.	1393330-36-3
Molecular Formula	C11H21BrO4
Molecular Weight	297.19 g/mol
Synonyms	2-(2-Bromoethoxy)ethyl 2,2-dimethylpropanoate; 2-(2-Bromoethoxy)ethyl pivalate; 2-(2-Bromoethoxy)ethyl trimethylacetate; tert-Butyl 2-(2-bromoethoxy)acetate (common misnomer); Br-PEG1-OtBu ester; Bromo-PEG1-t-butyl ester; Bromoethoxyethyl pivalate; Bifunctional PEG linker Br-PEG1-COOtBu
EINECS	Contact for details

Quality Control

Our Br-Peg1-Cootbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. The product is sensitive to strong acids and organic solvents; keep away from incompatible materials. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.