Description

7-Bromo-1-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound matters because it integrates a reactive bromine substituent with a stable trifluoromethyl group, offering a versatile scaffold for constructing complex molecules with tailored properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery, medicinal chemistry, and the development of novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis due to its halogen and fluorine functionalities.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Employed in the synthesis of advanced organic materials, such as liquid crystals or organic semiconductors.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form new carbon-carbon bonds.
• Fluorine Chemistry Building Block: The -CF3 group provides a source of fluorine for designing molecules with improved lipophilicity, bioavailability, and chemical stability.

Basic Information

Product Name	7-Bromo-1-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1391067-14-3
Molecular Formula	C10H9BrF3N
Molecular Weight	280.09 g/mol
Synonyms	7-Bromo-1-(trifluoromethyl)-3,4-dihydroisoquinoline; 1,2,3,4-Tetrahydro-7-bromo-1-(trifluoromethyl)isoquinoline; 7-Bromo-1-(trifluoromethyl)-1,2,3,4-tetrahydro-isoquinoline; 7-Bromo-1-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline; 1391067-14-3; 7-Br-1-CF3-THIQ
EINECS	Contact for details

Quality Control

Our 7-Bromo-1-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports your research and development needs with reliable, high-purity building blocks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.